Which organ is among the most common sites for cancer metastasis?

• A. Brain
• B. Adrenal gland
• C. Bone marrow
• D. Liver

Answer: (D)

Metastasis tends to lodge in organs with strong blood flow and environments that support tumor growth. The liver fits this pattern especially well because abdominal organs drain via the portal vein directly to the liver. This means tumor cells shed from many GI and abdominal cancers are carried straight to the liver, where the hepatic sinusoids can trap them and the liver’s rich blood supply and permissive microenvironment allow tumor growth. That combination makes the liver a common site of metastasis across a wide range of cancers, more so than the other organs listed. For some cancers, brain or bone marrow metastases occur, and adrenal involvement happens too, but the liver is the most frequently affected overall.