Which of the following is one of the most common sites of cancer metastasis?

• A. Liver
• B. Colon
• C. Reproductive tract
• D. White blood cells

Answer: (A)

When cancer spreads through the bloodstream, it often seeds organs with high blood flow and a filtering role. The liver fits that pattern perfectly, receiving a large volume of blood from the digestive tract via the portal vein. Its sinusoidal capillaries can trap circulating tumor cells, and the liver environment supports their growth, making liver metastases a very common occurrence, especially from colorectal cancers.

That’s why the liver is a typical destination for metastatic spread. The other options describe either primary sites (colorectal origin) or non-tolid targets (white blood cells) or less common destinations (reproductive tract) compared to the liver.